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(-)-Dexamethasone Acid

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Origin: China

Cas No: 37927-01-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 37927-01-8 Formula: C21H27FO5 Molecular Weight: 378.43400

    Description

    A glucocorticoid receptor of spleen tumor of human, a steroid for inhibiting angiogenesis and tumor growth and treating ocular hypertension.

    Basic Info

    Chemical Name (-)-Dexamethasone Acid
    Synonyms

    (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid;

    CAS No. 37927-01-8
    Molecular Formula C21H27FO5
    Molecular Weight 378.43400
    PSA 94.83000
    LogP 2.41890

    Properties

    Density 1.351g/cm3
    Boiling Point 566.865ºC at 760 mmHg
    Melting Point 274-277ºC
    Flash Point 296.63ºC
    Refractive Index 1.598

    Synthesis Route

    dexamethasone→(-)-Dexamethasone Acid
    11β,17α-dihydroxy-9α-fluoro-16α-methyl-3,20-dioxo-1,4-pregnadien-21-al→(-)-Dexamethasone Acid

    Precursor

    11β,17α-dihydroxy-9α-fluoro-16α-methyl-3,20-dioxo-1,4-pregnadien-21-al
    dexamethasone

    Downstream Product

    (11β,16α,17α)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxo-N-(2-sulfa nylethyl)androsta-1,4-diene-17-carboxamide
    (11β,16α,17α,11'β,16'α,17'α)-N,N'-(Disulfanediyldi-2,1-ethanediyl )bis(9-fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-1 7-carboxamide)

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