Home > Organosilicon Compounds> (1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine

(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine

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Origin: China

Cas No: 672314-45-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 672314-45-3 Formula: C23H41NOSi Molecular Weight: 375.66300

Description

Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters.

Basic Info

Chemical Name	(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
Synonyms	(1S)-1-[4-({[Dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)cycloh exyl]-N-[(1S)-1-phenylethyl]ethanamine;
CAS No.	672314-45-3
Molecular Formula	C23H41NOSi
Molecular Weight	375.66300
PSA	21.26000
LogP	6.94480

Synthesis Route

Methylmagnesium bromide+(R)-N-[(4'-tert-butyldimethylsilyloxymethyl-cyclohexyl)methylidene]-1-phenylethanamine→(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
1,4-Cyclohexanedimethanol→(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
(1R)-1-phenylethanamine→(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine

Precursor

Methylmagnesium bromide
(R)-N-[(4'-tert-butyldimethylsilyloxymethyl-cyclohexyl)methylidene]-1-phenylethanamine
tert-butyldimethylsilyl chloride
(1R)-1-phenylethanamine

Downstream Product

(R)-1-[4-(tert-Butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
tert-butyl N-[(1R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethyl]carbamate
(R)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine

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