Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Genitourinary system> (2,6-diethynyl-3a,5a-dimethyl-6-propanoyloxy-2,3,3b,4,5,7,8,8a,8b,9,10,10a-dodecahydro-1H-indeno[4,5-g]inden-3-yl) propanoate

(2,6-diethynyl-3a,5a-dimethyl-6-propanoyloxy-2,3,3b,4,5,7,8,8a,8b,9,10,10a-dodecahydro-1H-indeno[4,5-g]inden-3-yl) propanoate

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Origin: China

Cas No: 56470-64-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 56470-64-5 Formula: C28H38O4 Molecular Weight: 438.59900

Description

Anordrin (former developmental code name AF-53), also known as 2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol dipropionate, is a synthetic, steroidal estrogen that is used in China as a postcoital contraceptive. It is marketed in a combination formulation with mifepristone under the brand name Zi Yun. Anordrin is a selective estrogen receptor modulator, with both weak estrogenic and antiestrogenic properties. It binds to the estrogen receptor but does not bind to the androgen receptor or the progesterone receptor. In animals, anordrin has antigonadotropic effects, and in male animals, inhibits spermatogenesis and causes atrophy of the epididymis, prostate, and seminal vesicles. It produces a dihydroxylated active metabolite, anordriol, with similar but more potent estrogenic actions.

Basic Info

Chemical Name	(2,6-diethynyl-3a,5a-dimethyl-6-propanoyloxy-2,3,3b,4,5,7,8,8a,8b,9,10,10a-dodecahydro-1H-indeno[4,5-g]inden-3-yl) propanoate
Synonyms
CAS No.	56470-64-5
Molecular Formula	C28H38O4
Molecular Weight	438.59900
PSA	52.60000
LogP	5.14530

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Rodent - rat	2 mg/kg,female 1 day(s) after conception	1.Reproductive-Fertility-female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
Oral	TDLo - Lowest published toxic dose	Rodent - rat	7500 ug/kg,female 7-9 day(s) after conception	1.Reproductive-Fertility-other measures of fertility
Oral	TDLo - Lowest published toxic dose	Rodent - rat	500 ug/kg,female 1 day(s) after conception	1.Reproductive-Fertility-female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) 2.Reproductive-Fertility-pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

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