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(3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol

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Origin: China

Cas No: 252873-00-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 252873-00-0 Formula: C6H10O3 Molecular Weight: 130.14200

Description

An intermediate in the preparation of HIV-1 Protease Inhibitor. An isomeric impurity of Bisfuranol.

Basic Info

Chemical Name	(3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol
Synonyms	(3aR,4R,6aS)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-ol;
CAS No.	252873-00-0
Molecular Formula	C6H10O3
Molecular Weight	130.14200
PSA	38.69000
LogP	-0.25990

Synthesis Route

(3R,4'R)-3-(2',2'-dimethyl-[1',3']dioxolane-4'-yl)tetrahydrofuran-2-ol→(3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol
2,3-dihydrofuran+1,4-dioxane-2,5-diol→(3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol+(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol
(3R,3aR,6aS)-perhydrofuro[2,3-b]furan-3-yl acetate→(3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol

Precursor

(3R,4'R)-3-(2',2'-dimethyl-[1',3']dioxolane-4'-yl)tetrahydrofuran-2-ol
2,3-dihydrofuran
1,4-dioxane-2,5-diol
(3R,3aR,6aS)-perhydrofuro[2,3-b]furan-3-yl acetate

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