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(3R,5S)-Fluvastatin tert-Butyl Ester

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Origin: China

Cas No: 194934-96-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 194934-96-8 Formula: C28H34FNO4 Molecular Weight: 467.57200

Description

An intermediate for the preparation of (3R,5S)-Fluvastatin.

Basic Info

Chemical Name	(3R,5S)-Fluvastatin tert-Butyl Ester
Synonyms	tert-Butyl (E)-3,5-Dihydroxy-7-[3'-(4"-fluorophenyl)-1'-methylethylindol-2'-yl)hept-6-enoate;
CAS No.	194934-96-8
Molecular Formula	C28H34FNO4
Molecular Weight	467.57200
PSA	71.69000
LogP	5.88520

Properties

Appearance & Physical State	white solid
Density	1.13
Boiling Point	642.264ºC at 760 mmHg
Flash Point	342.229ºC

Synthesis Route

tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate→(3R,5S)-Fluvastatin tert-Butyl Ester
tert-Butyl acetate→(3R,5S)-Fluvastatin tert-Butyl Ester
(E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrylaldehyde→(3R,5S)-Fluvastatin tert-Butyl Ester

Precursor

(E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrylaldehyde
tert-Butyl acetate
tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate

Downstream Product

sodium,(E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

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