Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Brain and nervous system> (3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one

(3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 23930-19-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

Products Specification
Product Description

Property

CAS No.: 23930-19-0 Formula: C21H32O3 Molecular Weight: 332.47700

Description

Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use in both dogs and cats. Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin.
Unlike some of its predecessors alfaxalone is not associated with histamine release and anaphylaxis.; A study 1987 found the primary mechanism for the anaesthetic action of alfaxalone to be modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABAA cell surface receptors.
A 1994 study found that alfaxalone binds to a different region of this receptor than the benzodiazepines. These benzodiazepine-insensitive GABAA receptors are located extrasynaptically and are responsible for tonic inhibition. The occurrence of tonic GABAA inhibition coincides with the expression of relatively rare receptor subunits, particularly the α4, α6, and δ subunits, and as a rule of thumb, δ subunit-containing receptors are extrasynaptic.
Alfaxalone is metabolised rapidly in the liver. It has a very short plasma elimination half-life in dogs and cats.

Basic Info

Chemical Name	(3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one
Synonyms	Alfaxalone; Alphaxalone; Cyclothiazide; GR 2/234; 3alpha-Hydroxy-5alpha-pregnane-11,20-dione; 5alpha-Pregnan-3alpha-ol-11,20-dione;
CAS No.	23930-19-0
Molecular Formula	C21H32O3
Molecular Weight	332.47700
PSA	54.37000
LogP	3.77420

Properties

Density	1.112g/cm3
Boiling Point	468.1ºC at 760 mmHg
Flash Point	251ºC
Refractive Index	1.532
Vapor Pressure	9.95E-11mmHg at 25°C

Safety Info

Safety Statements	S22; S36
RIDADR	UN 2811 6.1/PG 3
Risk Statements	R22
Hazard Codes	Xn

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	297 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	116 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>2200 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Hot tags: (3r,5s,8s,9s,10s,13s,14s,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one, China, manufacturers, suppliers, factory, wholesale, low price, high quality