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((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol

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Origin: China

Cas No: 125224-43-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 125224-43-3 Formula: C12H16FNO Molecular Weight: 209.26000

Basic Info

Chemical Name	((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol
Synonyms	[(3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl]Methanol;
CAS No.	125224-43-3
Molecular Formula	C12H16FNO
Molecular Weight	209.26000
PSA	32.26000
LogP	1.83990

Properties

Density	1.104g/cm3
Boiling Point	327.2ºC at 760mmHg
Flash Point	151.7ºC
Refractive Index	1.514
Vapor Pressure	0mmHg at 25°C

Synthesis Route

methyl (3S,4R)-4-(4-fluorophenyl)piperidine-3-carboxylate→((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol
[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol→((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol
3-chloro-1-(4-fluorophenyl)propan-1-one→((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol

Precursor

1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one
3-chloro-1-(4-fluorophenyl)propan-1-one
methyl (3S,4R)-4-(4-fluorophenyl)piperidine-3-carboxylate
[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

Downstream Product

Paroxetine
tert-butyl (3S,4R)-4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine-1-carboxylate
Paroxetine hydrochloride hemihydrate

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