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8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine

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Origin: China

Cas No: 130642-57-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 130642-57-8 Formula: C20H21BrN2 Molecular Weight: 369.29800

Description

A derivative of Loratadine as dual antagonist of platelet activating factor (PAF) and histamine.

Basic Info

Chemical Name	8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
Synonyms	8-Deschloro-8-bromo-N-methyl Desloratadine;
CAS No.	130642-57-8
Molecular Formula	C20H21BrN2
Molecular Weight	369.29800
PSA	16.13000
LogP	4.40810

Synthesis Route

{3-[2-(3-Bromo-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone→8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
N-tert-butyl-3-methylpyridine-2-carboxamide→8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
3-[2-(3-Bromo-phenyl)-ethyl]-pyridine-2-carbonitrile→8-bromo-11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine

Precursor

3-[2-(3-Bromo-phenyl)-ethyl]-pyridine-2-carbonitrile
3-Bromobenzyl chloride
{3-[2-(3-Bromo-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone

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