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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
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8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

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Origin: China

Cas No: 31251-41-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 31251-41-9 Formula: C14H10ClNO Molecular Weight: 243.68800

    Description

    Loratadine intermediate. Loratidine impurity C.

    Basic Info

    Chemical Name 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
    Synonyms

    8-Chloro-10;
    D] cycloheptan-5-one;
    8-Chloro-10,11-dihydro-4-aza-5;

    CAS No. 31251-41-9
    Molecular Formula C14H10ClNO
    Molecular Weight 243.68800
    PSA 29.96000
    LogP 3.06460

    Properties

    Appearance & Physical State Yellow solid
    Density 1.313g/cm3
    Boiling Point 433.6ºC at 760mmHg
    Melting Point 90-92ºC
    Flash Point 216ºC
    Refractive Index 1.632

    Safety Info

    HS Code 2933990090
    Hazard Codes Xi

    Synthesis Route

    2-Cyano-3-(3-chlorophenylethyl)pyridine→8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
    3-(5-chloro-2-iodophenethyl)-N-methyl-N-phenylpicolinamide→8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
    3-[2-(3-chlorophenyl)ethyl]pyridine-2-carboxylic acid,hydrochloride→8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

    Precursor

    2-Cyano-3-(3-chlorophenylethyl)pyridine
    3-[2-(3-chlorophenyl)ethyl]pyridine-2-carboxylic acid,hydrochloride
    carbon atom
    N-phenyl-3-[2-(3-chlorophenyl)ethyl]-2-pyridine carboxamide

    Downstream Product

    desloratadine
    8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-5-ol
    Loratadine
    8-Chloro-11-(1-methylpiperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

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